The great Pharaoh Mino has died, and rule passes to his eldest son: Pharaoh Mido. Unhappy with the plain appearance of the pyramid in which his father was buried, Mido turns his attention to his own legacy. He wants his final resting place to better reflect his majesty and has ordered that 2-4 architects build pyramids set with jewels: a "pyramido". The architect who builds the most impressive pyramido will be appointed Vizier and will enjoy wealth and power beyond imagination.

Pyramido is a tile placement game in which each stage of the pyramid creates connections. Players take turns taking dominoes from the available selection to build their pyramid. To maximize their points, players must match the jewel icons on the dominoes and place their markers of the same color to activate the scoring areas. Each choice of a domino and its placement has a significant impact, as the previous stages influence the entire game.